Diastolic heart failure: diagnosis and therapy

@article{Nicoara2016DiastolicHF,
  title={Diastolic heart failure: diagnosis and therapy},
  author={Alina Nicoara and Mandisa-Maia Jones-Haywood},
  journal={Current Opinion in Anaesthesiology},
  year={2016},
  volume={29},
  pages={61–67}
}
Purpose of review This article focuses on the recent findings in the diagnosis and treatment of diastolic heart failure (DHF) or heart failure with preserved ejection fraction. Recent findings DHF has become the most common form of heart failure in the population. Although diastolic dysfunction still plays a central role, it is now understood that DHF is a very complex clinical entity with heterogeneous pathophysiology and significant contribution from extracardiac comorbidities. Alterations in… 
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17 Citations
Background Citations
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17 Citations

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The use of anesthetics in diastolic insufficiency should be further studied due to the implications it has at the cardiovascular level when inducing a patient.
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TLDR
Patients with HFmr EF and HFpEF could benefit from spironolactone treatment, with reduced hospitalizations, BNP levels, improved NYHA-FC, alleviated myocardial fibrosis by decreasing serum PICP in HFmrEF andHFpEF, decreased PIIINP levels and increased 6-MWD only in HFp EF.
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TLDR
To diagnose heart failure with preserved ejection fraction (HFpEF), the following three criteria have to be fulfilled: signs and symptoms generally present in heart failure, evidence of diastolic dysfunction and/or relevant structural cardiac alterations, and the presence of a normal LV end-diastolic volume.
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TLDR
Therapy, using fosinopril, in comparison with zofenoprill, more improved RAS (by 66.5%, p) and subjective evaluation of quality of life.
Heart Failure with Preserved Ejection Fraction: Current Diagnostic and Therapeutic Approach
TLDR
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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The results demonstrate that Sta protects against diastolic heart failure by attenuating myocardial hypertrophy and fibrosis via the TGF-β/Smad pathway.
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