Diastolic Hypotension and Myocardial Ischemia: A Reason to Remember Cuff Artifact in Blood Pressure Measurement.

  • J. David Spence
  • Published 2017 in Journal of the American College of Cardiology


high-sensitivity cardiac troponin T) and with coronary heart disease (CHD), stroke, or death (1). They concluded that particularly among subjects with systolic blood pressure $120 mm Hg, and thus elevated pulse pressure, low DBP was associated with subclinical myocardial damage and coronary events. In this insightful analysis, a very low DBP coupled with a high pulse pressure seemed to be very deleterious and these results put new perspective on studies that support lower targets for blood pressure lowering therapy (2). It has been shown that overaggressive antihypertensive treatment, that leads to low DBP and thus hypoperfusion of the coronary arteries, results in cardiac ischemic events (3). McEvoy et al. (1) focused their attention on DBP as the predominant determinant of coronary perfusion. However, it should be remarked that several factors in addition to DBP, such as perfusion time, vessel wall diameter, and vasomotor tone, may importantly affect coronary blood flow. It has been reported that any increase in heart rate (HR) impinges on diastolic time more than on systolic time, reduces the perfusion time, and leads to subendocardial ischemia, especially in patients with coronary artery disease (4). Furthermore, a large body of evidence indicates that high HR can be considered a strong predictor of cardiovascular morbidity and mortality in different clinical settings (4). In their report, the authors, unfortunately, did not address the association of HR with subclinical myocardial damage and events across the various DBP categories. Considering that HR is a simple parameter that strongly correlates with diastolic coronary flow it should be routinely taken into account for refining risk stratification of CHD in treated hypertensive patients.

DOI: 10.1016/j.jacc.2016.11.085

Cite this paper

@article{Spence2017DiastolicHA, title={Diastolic Hypotension and Myocardial Ischemia: A Reason to Remember Cuff Artifact in Blood Pressure Measurement.}, author={J. David Spence}, journal={Journal of the American College of Cardiology}, year={2017}, volume={69 12}, pages={1646-1647} }