Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysis.

  title={Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysis.},
  author={Denise Ecke and Bilha Fischer and Georg Reiser},
  journal={British journal of pharmacology},
  volume={155 8},
BACKGROUND AND PURPOSE The P2Y(11) receptor, a member of the group of metabotropic nucleotide receptors, shows a stereospecific ligand recognition of P(alpha)-substituted ATP derivatives (ATP-alpha-S isomers). These compounds are suitable candidates for the development of selective P2Y(11) receptor agonists that might be used as immune modulators. We have analysed the binding mode of ATP at the P2Y(11) receptor by molecular modeling and site-directed mutagenesis. Based on our recent findings… CONTINUE READING