Diastereoselective synthesis of unsaturated 1,4-amino alcohols as a biologically important moiety.

Abstract

The diastereoselective synthesis of unsaturated 1.4-amino alcohols can be achieved using chial allylic ethers with a hydroxyl group attached to the pi-system and chlorosulfonyl isocyanate. The enantioselectivity of the CSI reaction with the chiral allylic and benzylic ethers was examined in various solvents and temperatures. Based on these results, it was… (More)

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