Diastereoselective synthesis of diketopiperazine bis-α,β-epoxides.

Abstract

Functionalized diketopiperazines (dioxopiperazines) are an important class of molecules in medicinal chemistry and material science. Herein we report a diastereoselective synthesis of diketopiperazine bis-α,β-epoxides via the oxidation of exocyclic olefins. Although six diastereomers may be formed by this approach, only one or two of them were observed. 
DOI: 10.1021/jo102096d

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.