Diastereoselective, multicomponent access to trans-2-aryl-4-arylamino-1,2,3,4-tetrahydroquinolines via an AA'BC sequential four-component reaction and their application to 2-arylquinoline synthesis.

@article{Ribelles2013DiastereoselectiveMA,
  title={Diastereoselective, multicomponent access to trans-2-aryl-4-arylamino-1,2,3,4-tetrahydroquinolines via an AA'BC sequential four-component reaction and their application to 2-arylquinoline synthesis.},
  author={Pascual Ribelles and Vellaisamy Sridharan and Mercedes Villacampa and Ma Teresa Ramos and J Carlos Men{\'e}ndez},
  journal={Organic & biomolecular chemistry},
  year={2013},
  volume={11 4},
  pages={569-79}
}
The CAN-catalyzed reaction between 3,5-disubstituted anilines, vinyl ethers and aromatic aldehydes leads to trans-2-aryl-4-arylaminotetrahydroquinolines, in an AA'BC sequential multicomponent transformation related to the Povarov reaction that was also extended to the use of a second aniline as the C-4 substituent. The unusual trans stereochemistry was… CONTINUE READING