Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physico-chemical and Enzymological Properties

@inproceedings{Li2014DiastereomerSpecificRO,
  title={Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physico-chemical and Enzymological Properties},
  author={Qing Li and Oleksandr Plashkevych and Ram Shankar Upadhayaya and S. G. Deshpande and Andr{\'a}s F{\"o}ldesi and Jyoti R. Chattopadhyaya},
  year={2014}
}
Modified oligos (AON), with pure 20, 40-locked 70Sor 70R-Me-cLNA-A, -G, -C, and -T (Upadhayaya et al., J Org Chem 76:4408–4431, 2011; Srivastava et al., J Am Chem Soc 129:8362–8379, 2007), show higher RNA affinity and RNA Qing Li and Oleksandr Plashkevych contributed equally. Q. Li • O. Plashkevych (*) • R.S. Upadhayaya • S.G. Deshpande • A. Földesi • J. Chattopadhyaya (*) Chemical Biology Program, Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, Box 581, 751 23… CONTINUE READING
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