Diastereo- and enantioselective catalytic carbometallative aldol cycloreduction: tandem conjugate addition-aldol cyclization.

Abstract

A catalytic diastereo- and enantioselective method for tandem conjugate addition-aldol cyclization is described. This methodology enables the formation of five- and six-membered ring products from aromatic and aliphatic mono-enone mono-ketone precursors. Notably, in a single manipulation, three contiguous stereogenic centers are created with high levels of… (More)

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Cite this paper

@article{Cauble2003DiastereoAE, title={Diastereo- and enantioselective catalytic carbometallative aldol cycloreduction: tandem conjugate addition-aldol cyclization.}, author={David F Cauble and John D Gipson and Michael J Krische}, journal={Journal of the American Chemical Society}, year={2003}, volume={125 5}, pages={1110-1} }