Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.

@article{Matsumoto2013DiarylheptanoidsWI,
  title={Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.},
  author={Takahiro Matsumoto and Seikou Nakamura and Souichi Nakashima and Masayuki Yoshikawa and Katsuyoshi Fujimoto and Tomoe Ohta and Azumi Morita and Rie Yasui and Eri Kashiwazaki and Hisashi Matsuda},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2013},
  volume={23 18},
  pages={
          5178-81
        }
}
Structure of diarylheptanoids with antiallergic activity from the rhizomes of Curcuma comosa
The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit the release of β-hexosaminidase as a maker of degranulation from rat basophil leukemia
Diarylheptanoid analogues from the rhizomes of Zingiber officinale and their anti-tumour activity
TLDR
A gene enrichment analysis of the interacting targets indicated that diarylheptanoids were mainly associated with the anti-tumor activity by affecting DNA damage signaling pathway.
Lignan dicarboxylates and terpenoids from the flower buds of Cananga odorata and their inhibitory effects on melanogenesis.
TLDR
These isolated terpenoid derivatives may be promising therapeutic agents for the treatment of several skin disorders after showing an inhibitory effect on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.
Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
TLDR
The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition.
Phenolic compounds from the rhizome of Renealmia nicolaioides Loes.: a new diarylheptanoid.
TLDR
All four compounds are reported for the first time for this genus, and the first occurrence of compound 1 as a natural metabolite is reported here are unprecedented for the genus Renealmia.
Chemical constituents and biological research on plants in the genus Curcuma
TLDR
This review comprehensively summarizes the current knowledge on the chemistry and briefly discusses the biological activities of Curcuma species, with emphasis on anti-inflammatory and antitumor activities.
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TLDR
The ethyl acetate and 1-butanol soluble fractions of the roots of Pfaffia glomerata were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells, and a new noroleanane-type triterpene, pfaffianol A, its glycoside, and ecdysterone-type sterol glycosides were isolated.
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The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia japonica showed inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells and structure-activity relationships of the saponins were investigated.
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TLDR
Four diarylheptanoids, (5R)-1,7-bis (3,4-dihydroxyphenyl)-heptane-5-O-β-D-glucoside, were isolated from the bark of Alnus hirsuta Turcz and its inhibitory effects on melanogenesis by measuring the melanin level and tyrosinase activity in B16 melanoma cell were examined.
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TLDR
Ten cyclic diarylheptanoids, including three new compounds: myricanone 5-O-alpha-L-arabinofuranosyl-(1-->6)-beta-D-glucopyranoside, along with two flavonoids (11, 12), were isolated from the extracts of Myrica rubra (Myricaceae) bark.
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TLDR
First scientific investigation of a triterpene that displays an inhibitory effect on melanogenesis, but that also has an enhancing effect on fibroblast proliferation is reported, which could make camellioside B useful for treating skin disorders.
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