Diarylheptanoid hirsutenone prevents tumor necrosis factor-alpha-stimulated production of inflammatory mediators in human keratinocytes through NF-kappaB inhibition.

@article{Lee2009DiarylheptanoidHP,
  title={Diarylheptanoid hirsutenone prevents tumor necrosis factor-alpha-stimulated production of inflammatory mediators in human keratinocytes through NF-kappaB inhibition.},
  author={Chung Soo Lee and Hyun Hee Ko and Seong Jun Seo and Young Wook Choi and Min Won Lee and Soon Chul Myung and Hyoweon Bang},
  journal={International immunopharmacology},
  year={2009},
  volume={9 9},
  pages={1097-104}
}
Keratinocytes may play an important role in the pathogenesis of skin disease in atopic dermatitis. Diarylheptanoids such as oregonin and hirstanonol are demonstrated to have anti-inflammatory and anti-oxidant effects. The present study was to investigate the effect of hirsutenone, one of the diarylheptanoids, against tumor necrosis factor (TNF)-alpha-stimulated responses in human keratinocytes. Hirsutenone attenuated the TNF-alpha-induced production of cytokine IL-8, prostaglandin E(2) and… CONTINUE READING
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