Diarrhea in ulcerative colitis. The role of altered colonic sodium transport.

@article{Greig2000DiarrheaIU,
  title={Diarrhea in ulcerative colitis. The role of altered colonic sodium transport.},
  author={E R Greig and Geoffrey I. Sandle},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={915},
  pages={327-32}
}
In normal human colon, water and sodium (Na+) absorption are directly related. Defective Na+ absorption may therefore be an important factor in the pathogenesis of diarrhea in ulcerative colitis (UC). Electrophysiological studies have revealed profound decreases in channel-mediated apical Na+ entry and Na(+)-K(+)-ATPase-mediated basolateral Na+ extrusion in surface epithelial cells in inflamed human distal colon. Recent molecular biological studies indicate that mucosal inflammation in UC leads… CONTINUE READING
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