Diaphragmatic free radical generation increases in an animal model of heart failure.

@article{Supinski2005DiaphragmaticFR,
  title={Diaphragmatic free radical generation increases in an animal model of heart failure.},
  author={Gerald S. Supinski and Leigh A Callahan},
  journal={Journal of applied physiology},
  year={2005},
  volume={99 3},
  pages={1078-84}
}
Heart failure evokes diaphragm weakness, but the mechanism(s) by which this occurs are not known. We postulated that heart failure increases diaphragm free radical generation and that free radicals trigger diaphragm dysfunction in this condition. The purpose of the present study was to test this hypothesis. Experiments were performed using halothane-anesthetized sham-operated control rats and rats in which myocardial infarction was induced by ligation of the left anterior descending coronary… CONTINUE READING