Diaphragm sarcolemmal injury is induced by sepsis and alleviated by nitric oxide synthase inhibition.

@article{Lin1998DiaphragmSI,
  title={Diaphragm sarcolemmal injury is induced by sepsis and alleviated by nitric oxide synthase inhibition.},
  author={Marie C. M. Lin and Satoru Ebihara and Q El Dwairi and Sabah N. A. Hussain and Lin Yang and Stewart B. Gottfried and Alain Steve Comtois and Basil J Petrof},
  journal={American journal of respiratory and critical care medicine},
  year={1998},
  volume={158 5 Pt 1},
  pages={
          1656-63
        }
}
Endotoxemia is associated with impaired diaphragm contractility, and increased nitric oxide (NO) production has recently been implicated in this phenomenon. However, the precise nature of sepsis-related alterations in diaphragm myofiber function remains unclear. We tested the hypothesis that enhanced NO synthesis during sepsis produces diaphragm sarcolemmal injury with attendant abnormalities of myofiber membrane electrophysiology. Two different rat sepsis models were employed: acute (4 h… CONTINUE READING

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