Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.

  title={Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.},
  author={Pleuni E Hooijman and Albertus B Beishuizen and Christian C. Witt and Monique C. de Waard and Armand R J Girbes and Ang{\'e}lique M. E. Spoelstra-de Man and Hans W. M. Niessen and Emmy Manders and Hieronymus W. H. van Hees and Charissa E van den Brom and Vera M Silderhuis and Michael W. Lawlor and Siegfried Labeit and Ger J M Stienen and Koen J. Hartemink and Marinus A. Paul and Leo M. A. Heunks and Coen A. C. Ottenheijm},
  journal={American journal of respiratory and critical care medicine},
  volume={191 10},
RATIONALE The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To date, the nature of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood. OBJECTIVES We hypothesized that diaphragm muscle fibers of mechanically ventilated critically ill patients display atrophy and contractile weakness, and that the ubiquitin-proteasome pathway is… CONTINUE READING
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