Diaphragm development and congenital diaphragmatic hernia.

  title={Diaphragm development and congenital diaphragmatic hernia.},
  author={Robin D Clugston and John J. Greer},
  journal={Seminars in pediatric surgery},
  volume={16 2},
Advances in the understanding of normal diaphragm embryogenesis have provided the necessary foundation for novel insights into the pathogenesis of congenital diaphragmatic hernia (CDH). Although diaphragm formation is still not completely understood, we have identified key structures and periods of development that are clearly abnormal in animal models of CDH. The pleuroperitoneal fold (PPF) is a transient structure which is the target for the neuromuscular component of the diaphragm. The PPF… CONTINUE READING


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