Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells.

@article{Lizrraga2009DiaphanousrelatedFA,
  title={Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells.},
  author={F. Liz{\'a}rraga and R. Poincloux and M. Romao and Guillaume Montagnac and G. Le Dez and I. Bonne and Guillem Rigaill and G. Raposo and P. Chavrier},
  journal={Cancer research},
  year={2009},
  volume={69 7},
  pages={
          2792-800
        }
}
Proteolytic degradation of the extracellular matrix by metastatic tumor cells is initiated by the formation of invadopodia, i.e., actin-driven filopodia-like membrane protrusions endowed with matrix-degradative activity. A signaling cascade involving neural Wiskott-Aldrich syndrome protein and the Arp2/3 actin nucleating complex is involved in actin assembly at invadopodia. Yet, the mechanism of invadopodia formation is poorly understood. Based on their role as actin nucleators in cytoskeletal… Expand
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HDAC6 is required for invadopodia activity and invasion by breast tumor cells.
Spire-1 contributes to the invadosome and its associated invasive properties
Inhibitory cortactin nanobodies delineate the role of NTA‐ and SH3‐domain–specific functions during invadopodium formation and cancer cell invasion
Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes.
Regulation of MMP2/9 transport to the invadopodia during breast cancer cell invasion
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Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells.
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