Dianhydrogalactitol and neural tumors: an in vitro, in vivo preclinical evaluation.

@article{Helson1980DianhydrogalactitolAN,
  title={Dianhydrogalactitol and neural tumors: an in vitro, in vivo preclinical evaluation.},
  author={Lawrence Helson and P. W. Rozsa and E. O. Hajdu and J L Helson},
  journal={Cancer treatment reports},
  year={1980},
  volume={64 12},
  pages={1287-94}
}
The effects of dianhydrogalactitol on human neuroblastomas in vitro and in vivo as heterotransplants in nude mice were determined. Four neuroblastoma lines and three primitive neuroectodermal tumor lines were found, in vitro, to have different sensitivities to the drug. The most sensitive in in vitro assays was the neuroblastoma line SK-N-Mc. Tumors from patients resistant to cyclophosphamide were sensitive to dianhydrogalactitol in vitro and in nude mice. The lack of increased cytotoxicity in… CONTINUE READING