Diamond-Blackfan anemia: expansion of erythroid progenitors in vitro by IL-9, but exclusion of a significant pathogenetic role for the IL-9 gene and the hematopoietic gene cluster on chromosome 5q.

Abstract

Diamond-Blackfan anemia (DBA) is a congenital pure red blood cell aplasia that often requires lifelong transfusional therapy. Autosomal dominant and recessive inheritance have both been reported, suggesting genetic heterogeneity, but most cases occur sporadically. The origin of impaired erythropoiesis is unknown. Several erythroid growth factors have been… (More)

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@article{Dianzani1997DiamondBlackfanAE, title={Diamond-Blackfan anemia: expansion of erythroid progenitors in vitro by IL-9, but exclusion of a significant pathogenetic role for the IL-9 gene and the hematopoietic gene cluster on chromosome 5q.}, author={Irma Dianzani and Emanuela Garelli and Nicoletta Crescenzio and Fabio Timeus and Pier Giorgio Mori and Sergio M Varotto and Bruno Nobili and S{\'i}lvia Regina Brandalise and Nancy F. Olivieri and Vilma Gabutti and Ugo Ramenghi}, journal={Experimental hematology}, year={1997}, volume={25 12}, pages={1270-7} }