Diaminic carbonates, a new class of anti-inflammatory compounds: their biological characterization and mode of action.

@article{Porro1998DiaminicCA,
  title={Diaminic carbonates, a new class of anti-inflammatory compounds: their biological characterization and mode of action.},
  author={Giulia Porro and Giorgio Bertolini and Maria Antonietta Bonardi and Elisa Giovanetti and Patrick Lento and Francesca Leoni and Daniela Modena and Gianfranco Pavich and Florencia Marcucci},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={285 1},
  pages={193-200}
}
Taking advantage of a standard assay on mouse LM cells (murine fibroblast-like cells), we found that several diaminic carbonates, a new class of organic compounds synthesized in our laboratories, were able to inhibit human tumor necrosis factor alpha (huTNFalpha)-induced cytotoxicity in a dose-dependent manner. Structure-function relationship studies… CONTINUE READING