Dialyzable Leukocyte Extract (Transfer Factor) as Adjuvant Immunotherapy in the Treatment of Cancer

@inproceedings{Pineda2016DialyzableLE,
  title={Dialyzable Leukocyte Extract (Transfer Factor) as Adjuvant Immunotherapy in the Treatment of Cancer},
  author={Benjam{\'i}n Pineda and Ver{\'o}nica P{\'e}rez-de la Cruz},
  year={2016}
}
On 1955, Lawrence discovered that a dialyzed of viable leukocytes obtained from a healthy donor presenting a positive percutaneous tuberculin test was able to transfer to a healthy receptor the ability to respond to this pathogen. Lawrence named these molecules as Transfer Factor (TF). TF is composed of peptides obtained from lymphocytes ranging from 3500-6000 kDa. T lymphocytes have the ability to express delayed-type hypersensitivity and cell mediated immunity from sensitized donors to… Expand
Characterization and safety profile of Imuno TF®, a nutritional supplement for immune system regulation containing transfer factors
TLDR
The obtained analysis indicated Imuno TF®, a nutritional supplement composed of isolated transfer factors from porcine spleen, is a complex set of oligo- and polypeptides constituted of 163 different peptides which can potentially act on multiple mechanisms on the immune system pathways. Expand
Immunoregulatory effects of Imuno TF® (transfer factors) on Th1/Th2/Th17/Treg cytokines
TLDR
The role of Imuno TF® in the regulation of the immune responses is highlighted, which increased levels of mRNA and secretion of the anti-inflammatory cytokine IL-10, whereas it reduced levels of RNA and the secretion of pro- inflammatory cytokines IL-6 and TNF-α. Expand
Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation
TLDR
The obtained analysis indicated Imuno TF®, a nutritional supplement composed of isolated transfer factors from porcine spleen, is a complex set of oligo- and polypeptides constituted of 163 different peptides which can potentially act on multiple mechanisms on the immune system pathways. Expand
Postulated Adjuvant Therapeutic Strategies for COVID-19
TLDR
The scientific background on the hypothesis that these therapeutic agents can act in synergy in the prevention and improvement of COVID-19-associated symptoms is given. Expand
Effect of Sublingual Isolated Transfer Factors in a Case of Therapy Resistant Periungual Warts
TLDR
TF could be a possible effective alternative to treat therapy resistant PW and it is hoped this report will lead to further investigation, including controlled trials with TF in this patient group. Expand

References

SHOWING 1-10 OF 47 REFERENCES
Comparative studies on dialyzable leukocyte extracts containing transfer factor--a review.
TLDR
The term TF is now restricted to antigen-specific activity related to the promotion of dermal delayed-type hypersensitivity reactions and production of mediators of cellular immunity (lymphokines). Expand
Transfer factor: an overlooked potential for the prevention and treatment of infectious diseases.
TLDR
It seems that the preventative potential of transfer factor is as important as its therapeutic one, both discussed in this review. Expand
In vitro determination of effects of dialyzable leukocyte extracts containing transfer factor activity.
The studies for determining the effects of dialyzable leukocyte extracts (transfer factor) as reflected in recovery of E-rosetting capacity in trypsinised lymphocytes (recovery-assay) suggested theExpand
Structural Nature and Functions of Transfer Factors
  • C. Kirkpatrick
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1993
TLDR
Transfer factors appear to offer a novel means of molecular immunotherapy for certain patients with defective cell-mediated immunity and their reactivity probably explains the specificity of individual transfer factors. Expand
Transfer factor 1993: new frontiers.
  • H. Fudenberg, G. Pizza
  • Medicine
  • Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1994
Adoptive transfer of antigen-specific cell-mediated immunity in humans, first demonstrated by Lawrence [1] in 1949, opened a new avenue of research that has led both to increased understanding ofExpand
DIALYZABLE TRANSFER FACTOR IN THE TREATMENT OF HUMAN OSTEOSARCOMA: AN ANALYTIC REVIEW *
  • H. Fudenberg
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1976
TLDR
This work would answer the seven questions raised earlier concerning transfer factor as follows: Certianly, it does exist, and it does have a definite immunologic effect in humans, boosting cell-mediated immunity, as shown by a rise in the level of active T cells. Expand
Dialysable leucocyte extract (DLE) reduces lipopolysaccharide- induced tumour necrosis factor secretion in human leucocytes
TLDR
Testing the DLE effect in vitro on both TNF biological activity and its induction by lipopolysaccharide in human monocytes and whole blood from healthy donors suggests that ‘natural’ substances like DLE may be important immunomodulators in inflammatory diseases. Expand
Chemotactic activity in dialyzable transfer factor.
  • J. Gallin, C. Kirkpatrick
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1974
TLDR
Dialyzable transfer factor from human leukocytes was found to be strongly chemotactic for granulocytes and weakly chemOTactic for monocytes in vitro and in vivo and to have significance in relation to cell-mediated immune responses. Expand
Indications, usage, and dosage of the transfer factor.
TLDR
The group demonstrated that the TF increases the expression of IFN-gamma and RANTES, while decreases the expression in osteopontine, which is a good indication for the prescription of the TF. Expand
Ultrafiltered Pig Leukocyte Extract (UPLE, IMUNOR®) Potentiates Hematopoiesis–Stimulating Effects of G-CSF In Vitro and Improves the Outcome of Treatment of Hematopoietic Radiation Damage in Mice with G-CSF
TLDR
The results indicate the possibility of using UPLE, a commercially available preparation, for treatment of hematopoietic suppression of various etiology by evaluating the contingent ability of UPLE to potentiate the hematoiesis-stimulating effects of recobinant human granulocyte colony- Stimulating factor (G-CSF). Expand
...
1
2
3
4
5
...