Dialysis cultures with immobilized hybridoma cells for effective production of monoclonal antibodies.

Abstract

UNLABELLED An industrial scale reactor concept for continuous cultivation of immobilized animal cells (e.g. hybridoma cells) in a radial-flow fixed bed is presented, where low molecular weight metabolites are removed via dialysis membrane and high molecular products (e.g. monoclonal antibodies) are enriched. In a new "nutrient-split" feeding strategy… (More)
DOI: 10.1023/A:1007911517505

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Cite this paper

@article{Poertner1997DialysisCW, title={Dialysis cultures with immobilized hybridoma cells for effective production of monoclonal antibodies.}, author={Ralf Poertner and I L{\"u}demann and Herbert M{\"a}rkl}, journal={Cytotechnology}, year={1997}, volume={23 1-3}, pages={39-45} }