Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2.

@article{Kalayarasan2013DiallylsulfideAE,
  title={Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2.},
  author={Srinivasan Kalayarasan and N. Sriram and Syamala Soumyakrishnan and G. Sudhandiran},
  journal={Toxicology and applied pharmacology},
  year={2013},
  volume={271 2},
  pages={
          184-95
        }
}
Pulmonary fibrosis (PF) can be a devastating lung disease. It is primarily caused by inflammation leading to severe damage of the alveolar epithelial cells. The pathophysiology of PF is not yet been clearly defined, but studying lung parenchymal injury by involving reactive oxygen species (ROS) through the activation of protease activated receptor-2 (PAR-2) may provide promising results. PAR-2 is a G-protein coupled receptor is known to play an important role in the development of PF. In this… Expand
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