Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2

@article{Xiao2004DiallylTA,
  title={Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2},
  author={Dong Xiao and Sunga Choi and Daniel Ezra Johnson and Victor G. Vogel and Candace S. Johnson and Donald L. Trump and Yong Joo Lee and Shivendra V Singh},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={5594-5606}
}
Garlic-derived organosulfides (OSCs) including diallyl trisulfide (DATS) are highly effective in affording protection against chemically induced cancer in animals. Evidence is also mounting to indicate that some naturally occurring OSCs can suppress proliferation of cancer cells by causing apoptosis, but the sequence of events leading to proapoptotic effect of OSCs is poorly defined. Using PC-3 and DU145 human prostate cancer cells as a model, we now demonstrate that DATS is a significantly… CONTINUE READING
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