Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats

@article{Zhu2014DiallylTA,
  title={Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats},
  author={Xiaojing Zhu and Feng Zhang and Liang Zhou and Desong Kong and Li Chen and Yin Lu and Shizhong Zheng},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2014},
  volume={387},
  pages={445-455}
}
Liver fibrosis represents a frequent event following chronic insult to trigger wound healing reactions with accumulation of extracellular matrix (ECM) components in the liver. Activation of hepatic stellate cells (HSCs) is the pivotal event during liver fibrogenesis. The process of HSC activation is accompanied by enhanced expression of a series of marker proteins and pro-fibrogenic signal molecules. Natural products have been an important source of antifibrotic remedies. The present study aims… CONTINUE READING

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