Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats.

@article{Kalayarasan2009DiallylSE,
  title={Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats.},
  author={Srinivasan Kalayarasan and Ponnuraj Nagendra Prabhu and Narayanan Sriram and Ramar Manikandan and M. A. Manikandan Arumugam and Ganapasam Sudhandiran},
  journal={European journal of pharmacology},
  year={2009},
  volume={606 1-3},
  pages={162-71}
}
The protective role of diallyl sulfide (DAS) in attenuating gentamicin-induced nephrotoxicity has been reported earlier. However, the mechanism of induction of antioxidants by DAS in nephrotoxicity remains elusive. This study is aimed to elucidate the role of a transcription factor, Nuclear factor E2-related factor 2 (Nrf2) in inducing antioxidants and phase II enzymes during gentamicin toxicity in Wistar rats. DAS was administered intraperitoneally at a dosage of 150 mg/kg body weight once… CONTINUE READING
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