Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer

@inproceedings{Su2016DiallylDS,
  title={Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer},
  author={Bo Su and Jian Su and Ying Zeng and Fang Liu and Hong Xia and Yan-Hua Ma and Zhigang Zhou and Shuo Zhang and Bang-Min Yang and You-hua Wu and Xi Rui Zeng and Xiao-Hong Ai and Hui Ling and Hao Jiang and Qi Su},
  booktitle={Oncotarget},
  year={2016}
}
Diallyl disulfide (DADS) has been shown to have multi-targeted antitumor activities. We have previously discovered that it has a repressive effect on LIM kinase-1 (LIMK1) expression in gastric cancer MGC803 cells. This suggests that DADS may inhibit epithelial-mesenchymal transition (EMT) by downregulating LIMK1, resulting in the inhibition of invasion and growth in gastric cancer. In this study, we reveal that LIMK1 expression is correlated with tumor differentiation, invasion depth, clinical… CONTINUE READING