Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation.

@article{Knowles2000DiallylDI,
  title={Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation.},
  author={Lynn M. Knowles and John A. Milner},
  journal={Carcinogenesis},
  year={2000},
  volume={21 6},
  pages={1129-34}
}
Previous studies from our laboratory demonstrated that diallyl disulfide (DADS), an oil-soluble allyl sulfur compound found in processed garlic, markedly suppressed p34(cdc2) kinase activity and induced a G(2)/M phase arrest in cultured human colon tumor (HCT-15) cells. The present studies reveal that suppression of p34(cdc2) kinase activity by DADS does not result from direct interactions with the protein, but through changes in factors influencing the formation and conversion of the enzyme to… CONTINUE READING

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