Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis.

@article{Hassanein2021DiallylDA,
  title={Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis.},
  author={Emad H. M. Hassanein and Wafaa R. Mohamed and Marwa M. Khalaf and Abdel-Gawad S. Shalkami and Ahmed M. Sayed and Ramadan A. M. Hemeida},
  journal={Journal of food biochemistry},
  year={2021},
  pages={
          e13765
        }
}
Methotrexate (MTX) is a promising chemotherapeutic agent. Its medical use is limited by induced nephropathy. Our study was designed to explore the reno-protective effect of diallyl disulfide (DADS), an organosulfur compound of garlic oil, on MTX-induced nephropathy. Adult rats were randomly divided into 4 groups; normal control, DADS (50 mg kg-1  day-1 , p.o.), MTX (20 mg/kg, i.p.) and DADS+MTX. DADS significantly decreased serum creatinine, urea, uric acid, and albumin levels with an… 
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5 Citations

5 Citations

Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study

Analysis of the molecular and microscopic basis of MTX-induced toxicity in different organs and the possible protective effect of pycnogenol, a polyphenolic component extracted from the bark of P. pinaster, reveal that pyCNogenol successfully ameliorated oxidative damage and reduced toxicity, inflammatory response, and histological markers induced by methotrexate treatment.

Dual regulating of mitochondrial fusion and Timp-3 by leflunomide and diallyl disulfide combination suppresses diethylnitrosamine-induced hepatocellular tumorigenesis in rats.

The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling.

It is proposed that nutraceutical-specific targeting of RSS metabolism will lead to the design and development of even more efficacious antioxidant therapeutic strategies.

Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound

This review systematically evaluated the biological functions of DADS and discussed the underlying molecular mechanisms of these functions, hoping that this review provides guidance and insight into the current literature and enables future research and the development of D ADS for intervention and treatment of multiple diseases.

Tris(methylthio)methane produced by Mortierella hyalina affects sulfur homeostasis in Arabidopsis

Microbial volatiles are important factors in symbiotic interactions with plants. Mortierella hyalina is a beneficial root-colonizing fungus with a garlic-like smell, and promotes growth of…

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