Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis.

@article{Hassanein2021DiallylDA,
  title={Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis.},
  author={Emad H. M. Hassanein and Wafaa R. Mohamed and Marwa M. Khalaf and Abdel-Gawad S. Shalkami and Ahmed M. Sayed and Ramadan A. M. Hemeida},
  journal={Journal of food biochemistry},
  year={2021},
  pages={
          e13765
        }
}
Methotrexate (MTX) is a promising chemotherapeutic agent. Its medical use is limited by induced nephropathy. Our study was designed to explore the reno-protective effect of diallyl disulfide (DADS), an organosulfur compound of garlic oil, on MTX-induced nephropathy. Adult rats were randomly divided into 4 groups; normal control, DADS (50 mg kg-1  day-1 , p.o.), MTX (20 mg/kg, i.p.) and DADS+MTX. DADS significantly decreased serum creatinine, urea, uric acid, and albumin levels with an… 
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