Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis.

@article{Hassanein2021DiallylDA,
  title={Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis.},
  author={Emad H M Hassanein and Wafaa R. Mohamed and Marwa M. Khalaf and Abdel-Gawad S. Shalkami and Ahmed M. Sayed and Ramadan A. M. Hemeida},
  journal={Journal of food biochemistry},
  year={2021},
  pages={
          e13765
        }
}
Methotrexate (MTX) is a promising chemotherapeutic agent. Its medical use is limited by induced nephropathy. Our study was designed to explore the reno-protective effect of diallyl disulfide (DADS), an organosulfur compound of garlic oil, on MTX-induced nephropathy. Adult rats were randomly divided into 4 groups; normal control, DADS (50 mg kg-1  day-1 , p.o.), MTX (20 mg/kg, i.p.) and DADS+MTX. DADS significantly decreased serum creatinine, urea, uric acid, and albumin levels with an… 
1 Citations
Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound
TLDR
This review systematically evaluated the biological functions of DADS and discussed the underlying molecular mechanisms of these functions, hoping that this review provides guidance and insight into the current literature and enables future research and the development of D ADS for intervention and treatment of multiple diseases.

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