Diagonal electrophoresis for the detection of protein disulfides.

@article{McDonagh2012DiagonalEF,
  title={Diagonal electrophoresis for the detection of protein disulfides.},
  author={Brian McDonagh},
  journal={Methods in molecular biology},
  year={2012},
  volume={869},
  pages={309-15}
}
Cysteines are one of the most rarely used amino acids in proteins, therefore when conserved in proteins they usually play critical roles in structure, function, or regulation of the protein. These cysteines or thiols can be reversibly oxidised to sulfenic acid (-SOH), thiyl radicals (-S) or nitrosothiols (-SNO) or form both inter-and intra-disulfide bridges (PSSP). The protein thiol groups PSSPs, represent a larger active redox pool than glutathione and are likely to be directly involved in… CONTINUE READING

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