Diagnostic yield muscle biopsy in patients with clinical evidence of mitochondrial cytopathy.

@article{Rollins2001DiagnosticYM,
  title={Diagnostic yield muscle biopsy in patients with clinical evidence of mitochondrial cytopathy.},
  author={Sean M. Rollins and Richard A. Prayson and J T. Mcmahon and Bruce H. Cohen},
  journal={American journal of clinical pathology},
  year={2001},
  volume={116 3},
  pages={326-30}
}
We retrospectively reviewed 118 muscle biopsy specimens from 113 patients with clinical and/or biochemical evidence of mitochondrial cytopathy. Light microscopic evaluation revealed histologic abnormalities in 65 specimens. The most common histologic findings included angular atrophic esterase-positive muscle fibers, type II muscle atrophy, regenerating muscle fibers, and scattered cytochrome-oxidase deficient fibers. Ragged red fibers were noted in 3 specimens on a Gomori trichrome stain… CONTINUE READING
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