Diagnostic value of quantitative hepatic copper determination in patients with Wilson's Disease.

@article{Ferenci2005DiagnosticVO,
  title={Diagnostic value of quantitative hepatic copper determination in patients with Wilson's Disease.},
  author={P Ferenci and Petra Steindl-Munda and Wolfgang Vogel and Wolfgang Jessner and Michael Gschwantler and Rudolf E. Stauber and Christian Datz and Franz Hackl and Fritz Wrba and Peter Bauer and O. Thomas Lorenz},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2005},
  volume={3 8},
  pages={811-8}
}
BACKGROUND & AIMS A 5-fold increase of hepatic copper concentration is considered as the best available test for diagnosis of hepatic Wilson's disease (WD). However, the sensitivity and specificity of this test have never been fully investigated. METHODS Copper content was measured by flame atomic absorption spectroscopy in 114 liver biopsies obtained at diagnosis of WD, in 219 patients with noncholestatic liver diseases (including 144 with chronic hepatitis C and 44 with nonalcoholic fatty… CONTINUE READING
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