Diagnostic value of adenosine deaminase in nontuberculous lymphocytic pleural effusions

@article{JimnezCastro2003DiagnosticVO,
  title={Diagnostic value of adenosine deaminase in nontuberculous lymphocytic pleural effusions},
  author={David Jim{\'e}nez Castro and Gema D{\'i}az Nuevo and Esteban P{\'e}rez-Rodr{\'i}guez and Richard W. Light},
  journal={European Respiratory Journal},
  year={2003},
  volume={21},
  pages={220 - 224}
}
Adenosine deaminase (ADA) can aid in the diagnosis of tuberculous pleural effusions, but false-positive findings from lymphocytic effusions have been reported. The purpose of this study is to assess the ADA levels in nontuberculous lymphocytic pleural effusions (lymphocyte count >50%) of different aetiologies. Altogether, 410 nontuberculous lymphocytic pleural fluid samples were consecutively selected. These included malignant effusions (n=221), idiopathic effusions (n=76), parapneumonic… 

Role of Adenosine Deaminase Estimation in Differentiation of Tuberculous and Non-tuberculous Exudative Pleural Effusions

In this study, ADA levels in nontuberculous exudative pleural effusions rarely exceeded the cut-off; set for tuberculous disease.

Role of pleural fluid adenosine deaminase activity and lymphocytosis in the etiological diagnosis

Adenosine Deaminase activity (ADA) level in tubercular pleural effusion is markedly increased compared to non-tubercular effusions and ADA estimation being a simple colorimetric method is suitable for the rapid diagnosis of tubercular effusion.

Adenosine deaminase activity in pleural effusions of lymphoma patients.

The use of P-ADA in NHL effusion could aid the separation of transudates from exudates in non-Hodgkin's lymphoma patients.

[Adenosine deaminase activity in tuberculous and malignant pleural effusions].

It is concluded that ADA measured by the Giusti method proceeded by the dilution 1:8 of the pleural effusion samples very good differentiates tuberculous from malignant pleurisy, without the necessity to determine the 2'-deoxyadenosine/ adenosine ratio.

EFFICACY OF PLEURAL FLUID ADENOSINE DEAMINASE AND C-REACTIVE PROTEIN LEVELS IN EARLY DIFFERENTIAL DIAGNOSIS OF PLEURAL EFFUSION.

Pleural fluid ADA levels at a cutoff value of 40U/L, showed sensitivity, specificity, positive predictive value and negative predictive value of 91.67%, 89.3%, 88% & 92.6% respectively in tuberculous effusion and CRP levels in parapneumonic effusion were significantly higher compared to other types of effusions.

Diagnostic value of pleural fluid adenosine deaminase among the patients with pleural tuberculosis

In patients with unexplained exudative pleural effusion especially in those who were suspicious for tuberculous pleurisy, despite the low level of ADA, direct thoracoscopic pleural observation and multiple biopsies of pleura is highly recommended.

Diagnostic Accuracy of Adenosine Deaminase and Lymphocyte Proportion in Pleural Fluid for Tuberculous Pleurisy in Different Prevalence Scenarios

Adenosine deaminase (ADA) remains useful for the diagnosis of TPE even in low-to-intermediate prevalence scenarios when combined with the lymphocyte proportion.

Differential Diagnosis of Tuberculous and Malignant Pleural Effusions: What is the Role of Adenosine Deaminase?

There is no doubt that pleuroscopy-guided biopsy is of great value for TPE diagnosis; however, sensitivity and specificity of noninvasive tests, especially ADA, can help to distinguish between TB and malignancy.

Evaluation of Adenosine Deaminase (ADA) Activity for Diagnosis of Tubercular Pleural Effusion

It is concluded that ADA levels are significantly high in patients with tuberculous pleural effusion compared to that in non-tubercular group and can be made quickly in a noninvasive way.
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