Diagnostic utility of human cytomegalovirus-specific T-cell response monitoring in predicting viremia in pediatric allogeneic stem-cell transplant patients.

@article{Abate2012DiagnosticUO,
  title={Diagnostic utility of human cytomegalovirus-specific T-cell response monitoring in predicting viremia in pediatric allogeneic stem-cell transplant patients.},
  author={Davide A. Abate and Simone Cesaro and Simona Cofano and Marta Fiscon and Alda Saldan and Stefania Varotto and Carlo Mengoli and Marta Pillon and Elisabetta Calore and Maria Angela Biasolo and Riccardo Cusinato and Luisa Barzon and Chiara Messina and Modesto Ottaviano Carli and Giorgio Pal{\`u}},
  journal={Transplantation},
  year={2012},
  volume={93 5},
  pages={536-42}
}
BACKGROUND Several studies proved that virus-specific T-cells play a pivotal role in controlling cytomegalovirus (CMV) infection in adult allogeneic hematopoietic stem-cell transplant (HSCT) patients. Fewer data are available in pediatric HSCT settings, when immature and inexperienced immune system may affect antiviral immune reconstitution. METHODS We analyzed prospectively the CMV-specific T-cell reconstitution in a cohort of 31 pediatric allogeneic HSCT recipients at 30, 60, 90, 120, 180… CONTINUE READING
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