Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, and primary angiosarcomas of other sites.

@article{Ginter2014DiagnosticUO,
  title={Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, and primary angiosarcomas of other sites.},
  author={Paula S. Ginter and Juan Miguel Mosquera and Theresa Macdonald and Timothy Michael D'Alfonso and Mark A. Rubin and Sandra Jean Shin},
  journal={Human pathology},
  year={2014},
  volume={45 4},
  pages={709-16}
}
Breast cancer patients who receive radiation therapy or develop chronic lymphedema following axillary dissection can develop secondary mammary angiosarcomas (ASs) and, additionally, atypical vascular lesions (AVLs) in the former group. Recently, MYC amplification by fluorescence in situ hybridization (FISH) has been identified in secondary mammary AS but not in AVL and most primary mammary AS as well as AS of other sites. We studied MYC amplification and MYC protein expression in 7 radiation… CONTINUE READING

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Vascular lesions of the breast.

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High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma

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