Diagnostic specificity and familiality of early versus late evoked potentials to auditory paired stimuli across the schizophrenia-bipolar psychosis spectrum.

@article{Hamm2014DiagnosticSA,
  title={Diagnostic specificity and familiality of early versus late evoked potentials to auditory paired stimuli across the schizophrenia-bipolar psychosis spectrum.},
  author={Jordan P. Hamm and Lauren E. Ethridge and Nash N. Boutros and Matcheri S. Keshavan and John A. Sweeney and Godfrey D. Pearlson and Carol A. Tamminga and Brett A. Clementz},
  journal={Psychophysiology},
  year={2014},
  volume={51 4},
  pages={
          348-57
        }
}
Disrupted sensory processing is a core feature of psychotic disorders. Auditory paired stimuli (PS) evoke a complex neural response, but it is uncertain which aspects reflect shared and/or distinct liability for the most common severe psychoses, schizophrenia (SZ) and psychotic bipolar disorder (BDP). Evoked time-voltage/time-frequency domain responses quantified with EEG during a typical PS paradigm (S1-S2) were compared among proband groups (SZ [n = 232], BDP [181]), their relatives (SZrel… Expand
Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features
TLDR
This study constructively replicated prior B-SNIP1 research on auditory deviations observed during the paired stimuli task in SZ, SAD and BDP to identify biomarkers more closely related to affective versus nonaffective clinical phenotypes and neural distinctions between BDP and BDNP. Expand
Auditory steady-state EEG response across the schizo-bipolar spectrum
TLDR
Deviant auditory steady-state responses in the gamma range (30-90 Hz) may be translational biomarkers for schizophrenia (SZ) and were found across the schizo-bipolar spectrum at multiple frequencies with psychosis status and severity linked to greatest reductions at low and high gamma. Expand
Multivariate Genetic Correlates of the Auditory Paired Stimuli-Based P2 Event-Related Potential in the Psychosis Dimension From the BSNIP Study.
TLDR
Aberrant P2 component in psychosis was associated with gene networks regulating several fundamental biologic functions, either general or specific to nervous system development, plausibly implicated in psychosis. Expand
Functional cognitive and cortical abnormalities in chronic and first-admission schizophrenia
TLDR
Results suggest disruption of oscillatory dynamics at early stages of illness, which may contribute to deficient information sampling, memory updating, and higher cognitive functioning. Expand
The Importance of Auditory Cortex Abnormalities in Type I Bipolar Disorder
Functional and structural abnormalities of auditory cortices are associated with the neuropathology of schizophrenia [1-3]. Superior temporal lobe (STL) host primary and secondary auditory corticesExpand
Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.
TLDR
Study of two large samples of cases with schizophrenia, schizoaffective, and bipolar I disorder with psychosis, presentations with clinical features of hallucinations, delusions, thought disorder, affective, or negative symptoms found a biomarker approach to subtyping psychosis cases (called psychosis Biotypes) captured neurobiological homology that was missed by conventional clinical diagnoses. Expand
Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium
TLDR
It is hypothesized intrinsic activity is a critical differentiating feature for psychosis Biotypes, and neurobiologically defined psychosis subgroups may facilitate the use of intrinsic activity in translation models aimed at developing effective treatments for psychosis-relevant deviations in neural modulation. Expand
Is a paired-stimuli configuration necessary to obtain typical evoked response differences in studies of psychosis? An MEG study
TLDR
It is found that simple early auditory processing in psychosis may be largely independent of stimulus presentation condition, an outcome that may help re-frame future translational studies. Expand
Frequency-specific disruptions of neuronal oscillations reveal aberrant auditory processing in schizophrenia.
TLDR
Findings suggest abnormalities in auditory stimulus relevance processing in schizophrenia patients stem from insufficient amplification of salient stimuli. Expand
Identifying neural underpinnings of schizophrenia-specific disruptions in cognition using magnetic resonance imaging, individual differences, and genetics
Cognitive deficits are pronounced in psychotic disorders. Their relation to structural brain imaging measures have not been systematically investigated in a way that integrates multiple MRI andExpand
...
1
2
3
...

References

SHOWING 1-10 OF 71 REFERENCES
Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis.
TLDR
Results reveal a pattern of both unique and shared neurophysiological phenotypes occurring within major psychotic diagnoses, including accentuated prestimulus gamma oscillations and reduced P2 amplitudes and theta/alpha oscillations among participants with both SZ and BPP. Expand
Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder
TLDR
Although the P300 significantly differentiated psychotic groups from H, it did not uniquely discriminate groups beyond the above variables, perhaps indicating utility of this task for studying psychosis-associated neurophysiology generally and BPP specifically. Expand
Family history of psychosis moderates early auditory cortical response abnormalities in non‐psychotic bipolar disorder
TLDR
Auditory EEG responses are significantly reduced in unaffected relatives of psychosis patients, suggesting that they may relate to both psychosis liability and expression. Expand
Neurophysiological endophenotypes across bipolar and schizophrenia psychosis.
  • G. Thaker
  • Psychology, Medicine
  • Schizophrenia bulletin
  • 2008
TLDR
Several neurophysiological deficits in schizophrenia that frequently occur before the onset of psychosis may represent the intermediate phenotypes that index small effects of genes (and/or environmental factors) and the use of these measures in genetic studies may help the hunt for psychosis liability genes. Expand
Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension.
TLDR
These findings support SPEM predictive pursuit and lower frequency auditory ERP activity in a paired stimuli paradigm as putative endophenotypes of psychosis common to SZ and BD probands and relatives. Expand
Sensory gating event-related potentials and oscillations in schizophrenia patients and their unaffected relatives.
TLDR
The results suggest that ERO deficits in gamma to S1 and beta to S2 stimuli and impaired ERO gating are associated with SZ, but are not related to genetic liability for the illness. Expand
Abnormal Auditory N100 Amplitude: A Heritable Endophenotype in First-Degree Relatives of Schizophrenia Probands
TLDR
N100 amplitude is a heritable measure that is abnormal in patients and a subset of relatives for whom psychiatric comorbidity may be a genetically associated phenotype that is less viable as a schizophrenia endophenotype. Expand
Diminished suppression of the P50 auditory evoked potential in bipolar disorder subjects with a history of psychosis.
TLDR
A longitudinal history of psychosis in subjects with bipolar illness was associated with diminished suppression of the P50 auditory evoked potential, which may represent a common physiological mechanism associated with the vulnerability to psychosis in people withipolar illness as well as inPeople with schizophrenia. Expand
Clinical phenotypes of psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP).
TLDR
Symptoms, psychosocial functioning, and familial lineage overlap across the three DSM-IV psychosis diagnoses used in B-SNIP provide scant evidence for distinct phenotypic clustering around traditional phenomenological diagnoses. Expand
Contributions of spectral frequency analyses to the study of P50 ERP amplitude and suppression in bipolar disorder with or without a history of psychosis.
TLDR
The observed S1 effects in the low-frequency band suggest selective attention deficits in bipolar patients, especially those patients without a history of psychosis, which may reflect a diminished capacity to selectively attend to salient stimuli as opposed to impairments of inhibitory sensory processes. Expand
...
1
2
3
4
5
...