Diagnostic role of p16/INK4A protein in Human Papillomavirus (HPV) induced cervical dysplasia

Abstract

The p16/INK4A protein is a cellular regulatory polypeptide over-expressed in the presence of high levels of the Human Papillomavirus (HPV) coded E7 protein. This review outlines the use of p16 antigen staining in cervical biopsies as well as in PAP smears summarizing the corresponding literature and commenting the authors’ own experience. The p16 antigen is… (More)
DOI: 10.2478/s11535-010-0051-z

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