Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas

@article{Chiosea2008DiagnosticIO,
  title={Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas},
  author={Simion I Chiosea and Alyssa M. Krasinskas and Philip T. Cagle and Kisha Anne Mitchell and Dani S. Zander and Sanja Dacic},
  journal={Modern Pathology},
  year={2008},
  volume={21},
  pages={742-747}
}
Definitive diagnosis of malignant mesothelioma in small specimens can be extremely difficult based on morphology alone. Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as the most common genetic alteration in malignant mesotheliomas. Recent studies demonstrated that this alteration may be useful for differentiating benign from malignant mesothelial proliferations in cytology specimens. The aim of this study was to evaluate the diagnostic utility of homozygous… CONTINUE READING

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