Diagnostic complexities of eosinophilia.

@article{Montgomery2013DiagnosticCO,
  title={Diagnostic complexities of eosinophilia.},
  author={Nathan D. Montgomery and Cherie H. Dunphy and Micah J. Mooberry and Andrew Laramore and Matthew C. Foster and Steven I. Park and Yuri Fedoriw},
  journal={Archives of pathology \& laboratory medicine},
  year={2013},
  volume={137 2},
  pages={
          259-69
        }
}
CONTEXT The advent of molecular tools capable of subclassifying eosinophilia has changed the diagnostic and clinical approach to what was classically called hypereosinophilic syndrome. OBJECTIVES To review the etiologies of eosinophilia and to describe the current diagnostic approach to this abnormality. DATA SOURCES Literature review. CONCLUSION Eosinophilia is a common, hematologic abnormality with diverse etiologies. The underlying causes can be broadly divided into reactive, clonal… Expand
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References

SHOWING 1-10 OF 109 REFERENCES
Eosinophilic myeloid disorders: new classification and novel therapeutic strategies
  • J. Gotlib
  • Medicine
  • Current opinion in hematology
  • 2010
TLDR
Molecular/genetic analysis is now mandatory for the diagnosis, classification, and treatment of eosinophilic myeloid disorders and the finding of rearranged, constitutively activated PDGFRA/B identifies patients who are eminently treatable with tyrosine kinase inhibitors. Expand
Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment update.
TLDR
A simplified algorithm for distinguishing the various causes of clonal and idiopathic eosinophilia is provided and current therapy is discussed, including new drugs (imatinib mesylate, alemtuzumab, and mepolizumab). Expand
Practical approach to the patient with hypereosinophilia.
TLDR
Cognizant of the capacities of eosinophils to mediate tissue damage, the varied causes for hypereOSinophilia are considered, and a contemporary stepwise practical approach to the diagnosis and treatment of patients with hypereos inophilia is presented. Expand
Pathogenesis, classification, and therapy of eosinophilia and eosinophil disorders.
TLDR
Treatment of hypereosinophilic patients depends on the variant of disease, presence of end organ damage, molecular targets, and the overall situation in each case. Expand
The hypereosinophilic syndromes: current concepts and treatments
TLDR
A recent study showed that a monoclonal antibody to IL‐5, mepolizumab, reduced glucocorticoid therapy in HES patients who did not possess the FIP1L1‐PDGFRA mutation while controlling eosinophilia and preventing recurrence or progression of tissue damage. Expand
Pathogenesis of Hyper IgE Syndrome
TLDR
In depth study of the role of STAT3 mutations in specific aspects of HIES may lead to better understanding and new approaches to treatment of conditions intrinsic to HIES that are common in the general population, such as staphylococcal infections, scoliosis, osteoporosis, bronchiectasis, and arterial aneurysms. Expand
The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management
TLDR
The identification of a constitutively activated fusion tyrosine kinase on chromosome 4q12, derived from an interstitial deletion, that fuses the platelet-derived growth factor receptor-alpha gene (PDGFRA) to an uncharacterized human gene FIP1-like-1 (FIP1L1). Expand
The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management.
TLDR
The identification of a constitutively activated fusion tyrosine kinase on chromosome 4q12, derived from an interstitial deletion, that fuses the platelet-derived growth factor receptor-alpha gene (PDGFRA) to an uncharacterized human gene FIP1-like-1 (FIP1L1). Expand
Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.
TLDR
This study, the largest clinical analysis of patients with HES to date, provides useful information for clinicians but also should stimulate prospective trials to optimize treatment of HES. Expand
Familial eosinophilia: clinical and laboratory results on a U.S. kindred.
We describe a five-generation kindred with familial eosinophilia (FE; MIM131400), characterized by the occurrence of sustained eosinophilia of unidentifiable cause in multiple relatives. TheExpand
...
1
2
3
4
5
...