Diagnostic challenges of motility disorders: optimal detection of CD117+ interstitial cells of Cajal.

@article{Garrity2009DiagnosticCO,
  title={Diagnostic challenges of motility disorders: optimal detection of CD117+ interstitial cells of Cajal.},
  author={Megan M Garrity and Simon J. Gibbons and Thomas C. Smyrk and Jean Marie Vanderwinden and Pedro Julian Gomez-Pinilla and Anoop Nehra and Matthew Borg and Gianrico Farrugia},
  journal={Histopathology},
  year={2009},
  volume={54 3},
  pages={286-94}
}
AIMS Several gastrointestinal motility diseases are associated with altered numbers of interstitial cells of Cajal (ICC), and testing for alterations in numbers of ICC has been proposed as one way to improve routine diagnosis in motility diseases. However, the protocols currently used to visualize ICC in formalin-fixed paraffin-embedded (FFPE) tissue using antibodies to CD117 have not been optimized for studying motility disorders. The aims of this study were therefore to determine the optimal… CONTINUE READING

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