Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool.

@article{Prix2002DiagnosticBA,
  title={Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool.},
  author={Lothar Prix and Peter Uciechowski and Beatrix B{\"o}ckmann and Michael Giesing and Andreas Sch{\"u}tz},
  journal={Clinical chemistry},
  year={2002},
  volume={48 3},
  pages={428-35}
}
BACKGROUND Tumor cells that shed into stool are attractive targets for molecular screening and early detection of colon or pancreatic malignancies. We developed a diagnostic test to screen for 10 of the most common mutations of codons 12 and 13 of the K-ras gene by hybridization to a new biochip array. METHODS DNA was isolated from 26 stool samples by… CONTINUE READING