Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome.

@article{Sonneck2007DiagnosticAS,
  title={Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome.},
  author={Karoline Sonneck and Stefan Ioan Florian and Leonhard M{\"u}llauer and Friedrich Wimazal and Manuela F{\"o}dinger and Wolfgang R Sperr and Peter Valent},
  journal={International archives of allergy and immunology},
  year={2007},
  volume={142 2},
  pages={158-64}
}
BACKGROUND Patients with mastocytosis may suffer from severe hypotension after wasp or bee stings. In these patients, no specific IgE is detectable, but they usually have skin lesions and an elevated serum tryptase level. METHODS We report on 6 patients who were referred to our department because of severe hypotension following bee or wasp stings without cutaneous lesions. RESULTS In 3 patients, the baseline serum tryptase level was elevated (26, 36, and 67 ng/ml, respectively), and… CONTINUE READING

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