Diagnostic and prognostic value of nucleolar organizer regions in normal epithelium, dysplasia, and squamous cell carcinoma of the oral cavity.

BACKGROUND Nucleolar organizer regions (AgNORs) are associated with proliferative activity and represent a diagnostic aid and prognostic marker in several neoplastic entities. METHODS Sections from 51 T1-2 squamous cell carcinomas (SCC), 20 cases of dysplasia, and 8 specimens with normal epithelium were evaluated by 2 AgNOR counting methods: 1) the mean… CONTINUE READING