Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors.

@article{Yamaoka2006DiagnosticAP,
  title={Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors.},
  author={H. Yamaoka and K. Ohtsu and T. Sueda and T. Yokoyama and E. Hiyama},
  journal={Oncology reports},
  year={2006},
  volume={15 3},
  pages={
          551-6
        }
}
Hepatoblastoma (HBL), a major childhood malignant neoplasm, represents the most frequent malignant liver tumor in childhood. Recent reports have shown the CTNNB1 coding beta-catenin protein to be frequently mutated or deleted at hot-spot regions involving exon 3 in HBL. We investigated the genetic alterations of the CTNNB1 coding beta-catenin protein and expression of several genes downstream of Wnt signals in 4 benign and 17 malignant pediatric liver tumors (PLTs) consisting of 15 HBL, 1… Expand
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