Diagnostic and Prognostic Role of α-Fetoprotein in Hepatocellular Carcinoma: Both or Neither?

@article{Farinati2006DiagnosticAP,
  title={Diagnostic and Prognostic Role of α-Fetoprotein in Hepatocellular Carcinoma: Both or Neither?},
  author={Fabio Farinati and Dario Marino and Massimo De Giorgio and Anna Baldan and Maria Chiara Cantarini and Carmela Cursaro and Gian Ludovico Rapaccini and Paolo Poggio and Maria Anna Di Nolfo and Luisa Benvegn{\`u} and Marco Zoli and Franco Borzio and Mauro Bernardi and Franco Trevisani},
  journal={The American Journal of Gastroenterology},
  year={2006},
  volume={101},
  pages={524-532}
}
BACKGROUND:The clinical usefulness of α-fetoprotein (AFP) in hepatocellular carcinoma (HCC) management is debatable.OBJECTIVES:To assess, in a large multi-centric survey, diagnostic and prognostic reliability of AFP, predictive factors, and any correlation with the tumor immunophenotype.METHODS:A total of 1,158 patients with HCC were analyzed with reference to serum AFP levels at diagnosis. We evaluated: HCC grading, histotype, and size; Okuda, tumor–nodes–metastases (TNM), and Child-Pugh… CONTINUE READING
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