Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

@inproceedings{Bahr2018DiagnosticAO,
  title={Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study},
  author={Nathan C Bahr and Edwin Nuwagira and Emily E. Evans and Fiona V Cresswell and Philip V Bystrom and Adolf Byamukama and Sarah C Bridge and Ananta S Bangdiwala and David B. Meya and Claudia M Denkinger and Conrad K Muzoora and David R Boulware and Darlisha A. Williams and Kabanda Taseera and Dan Nyehangane and Mugisha Ivan and Patrick Orikiriza and Joshua Rhein and Kathy Huppler Hullsiek and Abdu Musubire and Katelyn A Pastick and Pamela Nabeta and James Mwesigye and Radha Rajasingham},
  booktitle={The Lancet. Infectious diseases},
  year={2018}
}
BACKGROUND WHO recommends Xpert MTB/RIF as initial diagnostic testing for tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about 50-70% and culture sensitivity of about 60%. We evaluated the diagnostic performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis. METHODS We prospectively… CONTINUE READING