Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

@inproceedings{Bahr2018DiagnosticAO,
  title={Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study},
  author={Nathan C Bahr and Edwin Nuwagira and Emily E Evans and Fiona V Cresswell and Philip V. Bystrom and Adolf Byamukama and Sarah C Bridge and Ananta S Bangdiwala and David B Meya and Claudia M Denkinger and Conrad K Muzoora and David G. Boulware and Darlisha A. Williams and Kabanda Taseera and Dan Nyehangane and Mugisha Ivan and Patrick Orikiriza and Joshua Rhein and Kathy Huppler Hullsiek and Abdu Musubire and Katelyn A Pastick and Pamela Nabeta and James Mwesigye and Radha Rajasingham},
  booktitle={The Lancet. Infectious diseases},
  year={2018}
}
BACKGROUND WHO recommends Xpert MTB/RIF as initial diagnostic testing for tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about 50-70% and culture sensitivity of about 60%. We evaluated the diagnostic performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis. METHODS We prospectively obtained diagnostic cerebrospinal fluid (CSF) specimens during screening for a trial on the treatment of HIV-associated cryptococcal meningitis in… CONTINUE READING
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