Diagnostic Utility of Fine Needle Aspiration Cytology of Sensory Cutaneous Nerve in Leprosy

Abstract

Background: Peripheral neuropathy is a central feature of leprosy. Intraneural inflammation caused by M. leprae is the morphological<lb>hallmark of this disease, FNAC of sensory cutaneous nerve has proved to be a valuable diagnostic tool. Methods: The data of patients with sensory cutaneous nerve involvement were retrieved from our record for the period from Nov 2014<lb>to Sept 2015. The hematoxylin and eosin (H and E)and May-Grünwald-Giemsa (MGG) stained slides were screened for Schwann cells,<lb>granuloma, and necrosis. Modified Ziehl-Neelsen (ZN) stained smears were searched for single lepra bacilli and globi. Results: Twenty-five sensory cutaneous nerves were aspirated. Out of which 19 yielded diagnostic aspirate. Five cytologic pictures were<lb>seen epithelioid cell granulomas (6), epithelioid cell granulomas with necrosis (3);necrosis + lepra bacilli (4); only lepra bacilli (2); and<lb>lymphocyte & macrophage infiltrate (4).Following the Ridley-Jopling classification, in our study there were 9 cases of TT, 4 of BT-TT,<lb>1 of BB, 2 of BL, and 3 of LL. Conclusion: FNAC of sensory cutaneous nerve is useful in diagnosis and classification of leprosy on the R-J scale.

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Cite this paper

@inproceedings{Reena2017DiagnosticUO, title={Diagnostic Utility of Fine Needle Aspiration Cytology of Sensory Cutaneous Nerve in Leprosy}, author={N . S . Reena and Sa Dilip Kumar and Panda Kishori}, year={2017} }