Diagnostic Performance of an Aspergillus-Specific Nested PCR Assay in Cerebrospinal Fluid Samples of Immunocompromised Patients for Detection of Central Nervous System Aspergillosis

@inproceedings{Reinwald2013DiagnosticPO,
  title={Diagnostic Performance of an Aspergillus-Specific Nested PCR Assay in Cerebrospinal Fluid Samples of Immunocompromised Patients for Detection of Central Nervous System Aspergillosis},
  author={Mark Reinwald and Dieter Buchheidt and Margit Hummel and Matthias Duerken and Hartmut Bertz and Rainer Schwerdtfeger and Stefan Reuter and M G Kiehl and Manuel Barreto-Miranda and Wolf-Karsten Hofmann and Birgit Spiess},
  booktitle={PloS one},
  year={2013}
}
Central nervous system (CNS) invasive aspergillosis (IA) is a fatal complication in immunocompromised patients. Confirming the diagnosis is rarely accomplished as invasive procedures are impaired by neutropenia and low platelet count. Cerebrospinal fluid (CSF) cultures or galactomannan (GM) regularly yield negative results thus suggesting the need for improving diagnostic procedures. Therefore the performance of an established Aspergillus-specific nested polymerase chain reaction assay (PCR) in… CONTINUE READING

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