Diagnostic Challenges in Celiac Disease and the Role of the Tissue Transglutaminase–Neo-Epitope

@article{Matthias2010DiagnosticCI,
  title={Diagnostic Challenges in Celiac Disease and the Role of the Tissue Transglutaminase–Neo-Epitope},
  author={T. Matthias and S. Pfeiffer and C. Selmi and M. Eric Gershwin},
  journal={Clinical Reviews in Allergy & Immunology},
  year={2010},
  volume={38},
  pages={298-301}
}
  • T. Matthias, S. Pfeiffer, +1 author M. Eric Gershwin
  • Published 2010
  • Medicine
  • Clinical Reviews in Allergy & Immunology
  • The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising… CONTINUE READING
    29 Citations

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Serologic Diagnosis of Celiac Disease: New Biomarkers.
    • 3
    Assessment of a Test for the Screening and Diagnosis of Celiac Disease
    • 19
    Novel trends in celiac disease
    • 30
    • PDF
    Serological Diagnosis of Celiac Disease –Moving Beyond the Tip of the Iceberg
    • 30
    • PDF
    Overview of biomarkers for diagnosis and monitoring of celiac disease.
    • I. Brusca
    • Medicine
    • Advances in clinical chemistry
    • 2015
    • 35
    Cutting-Edge Issues in Celiac Disease and in Gluten Intolerance
    • 73
    A new algorithm for the diagnosis of celiac disease
    • 20
    Digesting all the options: Laboratory testing for celiac disease
    • 9
    A Novel Algorithm for the Diagnosis of Celiac Disease and a Comprehensive Review of Celiac Disease Diagnostics
    • 35

    References

    SHOWING 1-10 OF 31 REFERENCES
    The pathogenesis of coeliac disease.
    • 105
    Current concepts of celiac disease pathogenesis.
    • 497
    Diagnostic accuracy of coeliac serological tests: a prospective study
    • 97
    IgA anti-tissue transglutaminase: setting the stage for coeliac disease screening
    • 29
    Pathomechanisms in Celiac Disease
    • 79
    Combination testing for antibodies in the diagnosis of coeliac disease: comparison of multiplex immunoassay and ELISA methods
    • 46
    Extraintestinal manifestations of celiac disease
    • 115
    • PDF
    Coeliac disease
    • 164
    • PDF
    Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa
    • 51