Diagnostic Challenges in Celiac Disease and the Role of the Tissue Transglutaminase–Neo-Epitope

  title={Diagnostic Challenges in Celiac Disease and the Role of the Tissue Transglutaminase–Neo-Epitope},
  author={T. Matthias and S. Pfeiffer and C. Selmi and M. Eric Gershwin},
  journal={Clinical Reviews in Allergy & Immunology},
  • T. Matthias, S. Pfeiffer, +1 author M. Eric Gershwin
  • Published 2010
  • Medicine
  • Clinical Reviews in Allergy & Immunology
  • The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising… CONTINUE READING
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