Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer

@article{Potter2003DiagnosticPA,
  title={Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer},
  author={Christian Potter and A. L. Harris},
  journal={British Journal of Cancer},
  year={2003},
  volume={89},
  pages={2 - 7}
}
The carbonic anhydrases (CAs) comprise a family of evolutionarily ancient enzymes found ubiquitously in nature. They have important roles in facilitating transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the unstirred layers of the extracellular space. The tumour-associated isoenzymes, CAIX and CAXII, are expressed in a wide variety of malignancies and appear to be tightly regulated by microenvironmental hypoxia. CAIX expression is linked to… CONTINUE READING

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